Publications

– Delaforge E., Kragelj J., Tengo L., Palencia A., Milles S., Bouvignies G., Salvi N., Blackledge M., Jensen MR. Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy. Journal of the American Chemical Society 140(3):1148-1158 (2018).

– DulicM., Cvetesic, N., Zivkovic, I.,Palencia, A., Cusack, S., Bertosa, B. & Gruic-Sovulj, I. Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase. Journal of Mol. Biol. 17:30517 (2018).

–  *Palencia, A.Bougdour, A., Brenier-Pinchart, MP., Touquet, B., Bertini, RL., Sensi, C., Gay, G., Vollaire, J., Josserand, V., Easom, E., et al. Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Molecular Medicine 9: 385-394 (2017).

– Sindikubwabo F., Ding S., Hussain T., Ortet P., Barakat M., Baumgarten S., Cannella D., Palencia A., Bougdour A., Belmudes L., Couté Y., et al. Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites. Elife 6:29391 (2017).

Pellegrini, E.,Palencia, A., Braun, L., Kapp, U., Bougdour, A., Belrhali, H., Bowler, MW. et al. Structural basis for the subversion of MAP kinase signalling by an intrinsically disordered parasite secreted agonist. Structure 25 (1): 16-26 (2017).

–  *Palencia, A., Liu, RJ., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, ED., Li, XF., Alley, MR., Freund, YR., Rosenthal, PJ., Hakimi, MA & Cusack, S. Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase. Antimicrobial agents and chemotherapy 60(10):5817-27 (2016).

 – Palencia, A., Chopra, S., Virus, C., Schulwitz, S., Temple, BR., Cusack, S. & Reader, J.Structural characterisation of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent. Nature comm  7:12928 (2016).

Palencia, A., Li, X., Bu, W., Ding, C., Easom, E., Feng, L., Hernandez, V., Houston, P., Liu, L., Meewan et al.Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase. Antimicrobial agents and chemotherapy 60(10):6271-80 (2016).

– Sonoiki, E., Palencia, A., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V., Zhang, YK., Choi, W., Gut, J., Legac, J., Cooper, R., Alley, MRK., et al. Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase. Antimicrobial agents and chemotherapy 60(8):4886-95 (2016).

– Aleksandrov, A., Palencia, A., Cusack, S. & Field M. Aminoacetylation reaction catalyzed by leucyl-tRNA synthetase operates via a self-assisted mechanism using a conserved residue and the aminoacyl substrate. J. Phys Chem B  120(19):4388-98 (2016).

Kragelj, J., Palencia, A., Nanao, MH., Maurin, D., Bouvignies, G., Blackledge, M.& Jensen, MR.Structure and dynamics of the MKK7-JNK signalling complex. Proceedings of the National Academy of Sciences of the United States of America 112(11):3409-14 (2015).

Zhao, H., Palencia, A., Seiradake, E., Ghaemi, Z., Cusack, S., Luthey-Schulten, Z., Martinis S. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol. 10 2277-85 (2015).

Schild, F. Kieffer-Jaquinod, S., Palencia, A., Cobessi, D., et al. Biochemical and biophysical characterization of the Selenium binding and reducing site in Arabidopsisthaliana homologue to mammals Selenium Binding Protein 1. Journal of biological chemistry 46:31765-76 (2014).

– Cvetesic, N., Palencia, A., Halasz, I., Cusack,S. & Gruic-Sovulj, I. The physiological target for LeuRS translational quality control is norvaline. EMBO J.  33(15):1639-53 (2014).

Borel, F., Hachi, I., Palencia, A.Gaillard, MC. & Ferrer, JL. Structure of mouse Mu-crystallin complexed with NADPH and the T3 thyroid hormone. FEBS Journal  281(6),1598-612 (2014).

Li, L., Palencia, A., Lukk, T., Li, Z., et al. Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens. Proceedings of the National Academy of Sciences of the United States of America 110, 3817-22 (2013).

– Palencia, A., Chopra, S., Virus, C., Tripathy, A., Temple, BR., Velazquez-Campoy, A., Cusack, S., et al. Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase. Nature comm  4, 1417 (2013).

– Hernandez, V., Crépin, T., Palencia, A., Cusack, S., et al. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrobial agents and chemotherapy 57, 1394-403 (2013); and Research highlight in Nature 494, 151 (2013).

Benoit, MP., Imbert, L., Palencia, A., Perard, J., Ebel, C., Boisbouvier, J. & Plevin, MJ. The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains. Nucleic acids research 41, 4241-52 (2013).

Palencia, A., Crepin, T., Vu, MT., Lincecum, TL., Martinis, SA. & Cusack, S. Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase. Nature structural & molecular biology 19, 677-84 (2012).

Xiol, J. Cora E., Koglgrubel, R., Chuma, S., Subramanian, S., Hosakawa, M., Reuter, M., Yang, Z., Berninger, P., Palencia, A., Venes, V., et al. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Molecular cell 47, 970-9 (2012).

Mathioudakis, N., Palencia, A., Kadlec, J., Round, A., Tripsianes, K., Satler, M., Pillai, RS., & Cusack, S. The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. RNA 18, 2056-72 (2012).

Crépin, T., Dias, A., Palencia, A., Swale, C., Cusack, S. & Ruigrok RW. Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit. Journal of virology 84, 9096-104 (2010).

Palencia, A., Camara-Artigas, A., Pisabarro, MT., Martinez, JC. & Luque, I. Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl. The Journal of biological chemistry 285, 2823-33 (2010).

Camara-Artigas, A., Palencia, A., Martinez, JC., et al. Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand. Acta cryst. Section D, Biological crystallography 63, 646-52 (2007).

Palencia, A., Martinez, JC., Mateo, PL., Luque, I. & Camara-Artigas, A. Structure of human TSG101 UEV domain. Acta cryst. Section D, Biological crystallography 62, 458-64 (2006).

Palencia, A., Cobos, ES., Mateo, PL., Martinez, JC. & Luque, I. Thermodynamic dissection of the binding energetics of proline-rich peptides to the Abl-SH3 domain: implications for rational ligand design. Journal of molecular biology 336, 527-37 (2004).

Contact: andres.palencia [ at] univ-grenoble-alpes.fr