Job Description
Research Technician Position Available
Protein Expression and Purification Scientist, Biochemist, Structural Biologist
A research technician position is available in the group Structural Biology of Novel Drug Targets in Human Diseases (https://noveltargets-palencia.com), at the Institute for Advanced Biosciences (Grenoble) to work on the expression, purification of protein-RNA complexes for structural studies, and their interactions with inhibitors in the field of infectious diseases and cancer.
In addition to structural biology and biophysical techniques, our laboratory also uses a wide range of approaches, from biochemistry and genetics to in vivo animal studies (in collaboration). We seek an outstanding candidate with training in molecular biology, protein/RNA biochemistry, with a strong interest in structural biology –crystallography or cryo-electron microscopy (EM)– to support the study of novel protein drug targets.
The successful candidate will use the in-house IAB facilities for protein production in different systems; other structural biology facilities of the Partnership for Structural Biology in Grenoble (EMBL-ESRF-IBS-ILL, http://www.psb-grenoble.eu); and will interact with industrial partners.
Applicants should possess experience in molecular biology and protein production by using mammalian cells, bacteria or insect cells. Experience in the assembly and purification of protein-RNA complexes, crystallization and/or preparation of samples for EM studies would be an advantage. Motivation to work in a multidisciplinary and international environment is fundamental.
The candidate will work in the heart of the French Alpes (Grenoble) at the Institute for Advanced Biosciences (IAB), where creativity and excellence are fundamental to advance biomedical research and science education. The IAB is a research center of the University of Grenoble-Alpes, the French National Institute of Health and Medical Research (INSERM), and the French National Center for Scientific Research (CNRS). Grenoble provides access to state-of-the-art structural biology technologies available at the ESRF, EMBL, IBS and ILL. This includes new EM facilities equipped with Titan Krios, and Glacios/Falcon III. Other facilities include the ESRF synchrotron X-ray beamlines, high-field NMR at the IBS as well as the high-throughput crystallization platform at the EMBL, mammalian and insect cell facilities, and the biophysical platform. The lab has access to other synchrotrons: DLS, DESY, SOLEIL, and SLS.
Applicants should provide a motivation letter and a CV with contact information for two or more referees.
For additional information please visit:
Research Group Website: https://noveltargets-palencia.com
Institute for Advanced Biosciences: https://iab.univ-grenoble-alpes.fr/?language=en
Job Location: Grenoble, France
Position Type: Full-Time/Regular
Starting Contract: 24 Months (renewable)
Starting Date: Immediate